55 research outputs found

    10 simple rules to create a serious game, illustrated with examples from structural biology

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    Serious scientific games are games whose purpose is not only fun. In the field of science, the serious goals include crucial activities for scientists: outreach, teaching and research. The number of serious games is increasing rapidly, in particular citizen science games, games that allow people to produce and/or analyze scientific data. Interestingly, it is possible to build a set of rules providing a guideline to create or improve serious games. We present arguments gathered from our own experience ( Phylo , DocMolecules , HiRE-RNA contest and Pangu) as well as examples from the growing literature on scientific serious games

    DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

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    We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

    Apprentissage avec et sans conscience

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    Is it possible to learn without awareness? If so, what can learn without awareness, and what are the different mechanisms that differentiate between learning with and without consciousness? How can best measure awareness?Here are a few of the many questions that I have attempted to investigate during the past few years. The main goal of this thesis was to explore the differences between conscious and unconscious learning. Thus, I will expose the behavioral and computational explorations that we conducted during the last few years. To present them properly, I first review the main concepts that, for almost a century now, researchers in the fields of neuroscience have formulated in order to tackle the issues of both learning and consciousness. Then I detail different hypotheses that guided our empirical and computational explorations. Notably, a few series of experiments allowed identification of several mechanisms that participate in either unconscious or conscious learning. In addition we explored a computational framework for explaining how one could learn unconsciously and nonetheless gain subjective access to one’s mental events. After reviewing the unfolding of our investigation, I detail the mechanisms that we identified as responsible for differences between learning with and without consciousness, and propose new hypotheses to be evaluated in the future.Doctorat en Sciences Psychologiques et de l'éducationinfo:eu-repo/semantics/nonPublishe

    Consciousness and metarepresentation: A computational sketch

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    Learning to be conscious: A metacognitive model of awareness

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